San Francisco is taking aggressive steps to combat its ongoing drug overdose epidemic, with the Department of Public Health rolling out innovative strategies to save lives and support those battling substance use disorder.

In January 2026, the city recorded 53 unintentional overdose deaths, a significant increase from December’s 36 deaths. While these numbers are lower than previous years, city officials remain deeply committed to addressing the crisis, particularly the devastating impact of fentanyl.

Department of Public Health Director Daniel Tsai is spearheading a multi-pronged approach focused on early intervention and treatment. One groundbreaking initiative involves San Francisco Jail Health Services introducing injectable buprenorphine, a medication that helps reduce drug cravings and withdrawal symptoms.

Dr. Tyler Mains, Chief Medical Officer of Jail Health Services, describes the injectable treatment as a “game changer”. Unlike previous oral treatments that required days of waiting, this new method allows patients to start medication just eight hours after arrest, with the treatment remaining effective for several days.

In the pilot’s first month, 115 inmates received the injectable treatment, with approximately half following up for continued care within 30 days of release. This approach represents a significant shift in addressing substance use disorder, focusing on treatment and support rather than punishment.

Additionally, Mayor Daniel Lurie is developing a RESET Center, a comprehensive facility designed to provide mental health and substance use treatment services. Expected to open in the spring near the Hall of Justice, this center aims to offer an alternative to traditional incarceration for individuals struggling with drug-related issues.

These innovative strategies reflect San Francisco’s commitment to compassionate, evidence-based approaches to addressing the complex challenges of addiction. By prioritizing treatment, support, and early intervention, the city hopes to reduce overdose deaths and help individuals reclaim their lives.